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Thyroid Cancer Pipeline Landscape Analysis: 40+ Key Players & 40+ Pipeline Drugs

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Thyroid Cancer Pipeline Landscape Analysis: 40+ Key Players & 40+ Pipeline Drugs

November 15
21:28 2022
Thyroid Cancer Pipeline Landscape Analysis: 40+ Key Players & 40+ Pipeline Drugs

DelveInsight’s, “Thyroid Cancer Pipeline Insight, 2022,” report provides comprehensive insights about 40+ companies and 40+ pipeline drugs in Thyroid Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

 

In the Thyroid Cancer Pipeline report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Thyroid Cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

 

Key takeaways from the Thyroid Cancer Pipeline Report

  • DelveInsight’s Thyroid Cancer Pipeline analysis depicts a robust space with 40+ active players working to develop 40+ pipeline treatment therapies.
  • The leading Thyroid Cancer Companies are working such as Shanghai Henlius Biotech, AffyImmune Therapeutics, Inc., Taizhou Hanzhong biomedical co. LTD,  Bristol-Myers Squibb, Takeda Oncology, Merck Sharp & Dohme Corp., Genentech, Inc., VBL Therapeutics, Eli Lilly and Company,  Chia Tai Tianqing Pharmaceutical Group Co., Ltd., CSPC ZhongQi Pharmaceutical Technology Co., Ltd., Purple Biotech, Boston Pharmaceuticals, Xynomic Pharmaceuticals, Inc., Turning Point Therapeutics, Inc., Iovance Biotherapeutics, Inc., Hoffmann-La Roche, Hutchison Medipharma Limited, Theratechnologies, TransThera Sciences (Nanjing), Inc., Novartis Oncology, SOTIO Biotech AG, Ono Pharmaceutical, Debiopharm, Tmunity Therapeutics, Codiak BioSciences, Oncoceutics, GlobeImmune, C4 Therapeutics, Innovative Cellular Therapeutics, Applied Pharmaceutical, and others are developing novel drug candidates to improve the Thyroid Cancer treatment landscape.
  • Promising Thyroid Cancer pipeline therapies in various stages of development include HLX208, AIC100, HX008, Nivolumab, Ipilimumab, MLN0128, Pembrolizumab, Vemurafenib, VB-111, LOXO-260, Anlotinib hydrochloride, HA121-28, CM-24, BOS172738, XP-102, TPX-0046, LN 145, Alectinib, Surufatinib, TH1902, TT-00420, Spartalizumab, SO-C101, LY3410738, Binimetinib, DEBIO 1124, CDK-002, ONC201, GI 6207, APS03118, exoASO STAT6, and others.
  • The companies and academics are working to assess challenges and seek opportunities that could influence Thyroid Cancer R&D. The therapies under development are focused on novel approaches to treat/improve Thyroid Cancer.

 

Request a sample and discover the recent advances in Thyroid Cancer Medication @ Thyroid Cancer Treatment Landscape

 

Thyroid Cancer Overview

Thyroid cancer starts in the cells that make up your thyroid gland. The thyroid gland makes hormones that help control many processes in your body. Thyroid cancer is relatively common enough so that all of us will know somebody with thyroid cancer. There are more than 50,000 new cases of thyroid cancer each year in the United States. Women are more likely to develop thyroid cancer at a ratio of three to one. Thyroid cancer can occur in any age group, although it is most common after age 30 and its aggressiveness increases significantly in patients above 55 years of age. Thus, most people with thyroid cancer are women over age 30. The majority of patients present with a nodule on their thyroid which typically does not cause symptoms. Remember, likely over 90% of thyroid nodules are not cancer. But, when a thyroid cancer does begin to grow within a thyroid gland, it almost always does so within a discrete nodule within the thyroid. Said differently, the entire thyroid isn’t a cancer; the cancer grows from within a nodule which is within the thyroid. It’s normal to have few or no symptoms early on. One of the most common symptoms is a lump (growth) called a nodule in the neck. This might be found during a routine physical. Most thyroid nodules are not cancer. A biopsy is the only way to know for sure that you have thyroid cancer. Small pieces of tissue are taken from the thyroid and tested for cancer. The treatment choices depends on the type of thyroid cancer person have, test results, the stage of the cancer, and the overall health. Most thyroid cancers are slow to grow and spread (metastasize). But some kinds can grow and spread quickly.

 

Recent Developmental Activities in the Thyroid Cancer Pipeline Report

  • In April 2022, Molecular Targeting Technologies Inc. (MTTI) and ITM Isotope Technologies Munich SE (ITM) announced the signing of a global clinical supply agreement that provides MTTI with ITM’s medical radioisotope no-carrier-added lutetium-177 (n.c.a. 177Lu / EndolucinBeta®) for the preclinical and clinical development as well as potential commercial production of MTTI’s radiopharmaceutical candidate n.c.a. 177Lu-EBTATE to treat a range of cancers. N.c.a. 177Lu-EBTATE is currently in clinical development for the treatment of neuroendocrine tumors, a special form of thyroid cancer (Hürthle cell), and a rare type of head and neck cancer (nasopharyngeal cancer).
  • In April 2022, Purple Biotech Ltd., announced favorable safety and efficacy data supporting the advancement of CM24, a first-in-class clinical-stage monoclonal antibody with the potential to treat multiple solid tumor cancers.
  • In January 2022, Applied Pharmaceutical Science, Inc. announced the Investigational New Drug (IND) application for APS03118, a next-generation selective RET inhibitor, which has been approved by the U.S. Food and Drug Administration (FDA). The clinical application is also in the process of being submitted to the National Medical Products Administration (NMPA) in China, and a global multi-center clinical trial is in the pipeline for initiation in the second quarter of 2022 in the U.S., China, and Australia, etc.
  • In May 2021, AffyImmune Therapeutics announced that the US Food and Drug Administration (FDA) granted Fast Track designation to its lead compound, AIC100, for the treatment of anaplastic thyroid cancer and refractory poorly differentiated thyroid cancer

 

Thyroid Cancer Emerging Drugs

Donafenib: Suzhou Zelgen Biopharmaceuticals

Donafenib, an orally administered multikinase inhibitor, is being developed by Suzhou Zelgen Biopharmaceuticals for the treatment of Late stage cancers. The product targets Raf kinase and various receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Currently, it is in phase 3 of development stage for the treatment of thyroid cancer. 

Anlotinib: Jiangsu Chia-Tai Tianqing Pharmaceutical

Anlotinib is an orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptors (PDGFR), and c-kit. Currently, it is in phase 3 of development stage for the treatment of thyroid cancer. 

Nivolumab: Bristol-Myers Squibb

Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including the anti-tumor immune response. Currently, it is in phase 2 of development stage for the treatment of thyroid cancer. 

RX208: Suzhou NeuPharma

RX108 is a novel small-molecule inhibitor of sodium-potassium adenosine triphosphatase (Na+/K+-ATPase). Na+/K+-ATPase is an ion carrier protein and controls transportation of Na+ and K+ across the cell membrane. Studies have shown that Na+/K+-ATPase serves as a scaffold for the assembly of multiple-protein signaling complex and plays an important role in the regulation of cell growth, motility, and proliferation beyond that of ion transport.  Expression of Na+/K+-ATPase is elevated in various tumors. Inhibition of Na+/K+-ATPase in cancer cells triggers a series of downstream signaling activities that lead to cell-cycle arrest, apoptosis and autophagic cell death. Targeting Na+/K+-ATPase offers a potential new approach for the development of novel anti-cancer therapies. 

AIC100: AffyImmune Therapeutics

AffyImmune’s lead product, AIC100, is an affinity-tuned, ICAM-1 targeted, third generation CAR T cell therapy. AIC100’s CAR has an affinity to ICAM-1 similar to the affinity between naturally-occurring T cells and their targets, which is much lower than most CARs used to date and reduces on-target off-tumor toxicities. AIC100 also expresses SSTR2 for real-time monitoring of CAR T cell distribution and activity.Preclinical studies demonstrate that AIC100 induces robust and enduring tumor eradication without toxicity-related relapse or fatality in various solid tumor models. Studies also suggest the potential for combination with anti-PD-1 therapies. AffyImmune is currently enrolling patients in our Phase I trial for ARTC.

 

Learn more about the emerging Thyroid Cancer pipeline therapies @ Thyroid Cancer Clinical Trials

 

Thyroid Cancer Pipeline Therapeutic Analysis

There are approx. 40+ key companies which are developing the therapies for Thyroid Cancer. The companies which have their Thyroid Cancer drug candidates in the most advanced stage, i.e. phase III include, Suzhou Zelgen Biopharmaceuticals.

 

Scope of the Thyroid Cancer Pipeline Report

  • Coverage- Global
  • Thyroid Cancer Therapeutic Assessment by Product Type
  • Thyroid Cancer Therapeutic Assessment by Stage and Product Type
  • Thyroid Cancer Therapeutic Assessment by Route of Administration
  • Thyroid Cancer Therapeutic Assessment by Stage and Route of Administration
  • Thyroid Cancer Therapeutic Assessment by Molecule Type
  • Thyroid Cancer Therapeutic Assessment by Stage and Molecule Type
  • Thyroid Cancer Pipeline Companies- Shanghai Henlius Biotech, AffyImmune Therapeutics, Inc., Taizhou Hanzhong biomedical co. LTD,  Bristol-Myers Squibb, Takeda Oncology, Merck Sharp & Dohme Corp., Genentech, Inc., VBL Therapeutics, Eli Lilly and Company,  Chia Tai Tianqing Pharmaceutical Group Co., Ltd., CSPC ZhongQi Pharmaceutical Technology Co., Ltd., Purple Biotech, Boston Pharmaceuticals, Xynomic Pharmaceuticals, Inc., Turning Point Therapeutics, Inc., Iovance Biotherapeutics, Inc., Hoffmann-La Roche, Hutchison Medipharma Limited, Theratechnologies, TransThera Sciences (Nanjing), Inc., Novartis Oncology, SOTIO Biotech AG, Ono Pharmaceutical, Debiopharm, Tmunity Therapeutics, Codiak BioSciences, Oncoceutics, GlobeImmune, C4 Therapeutics, Innovative Cellular Therapeutics, Applied Pharmaceutical, and others
  • Thyroid Cancer Therapies- HLX208, AIC100, HX008, Nivolumab, Ipilimumab, MLN0128, Pembrolizumab, Vemurafenib, VB-111, LOXO-260, Anlotinib hydrochloride, HA121-28, CM-24, BOS172738, XP-102, TPX-0046, LN 145, Alectinib, Surufatinib, TH1902, TT-00420, Spartalizumab, SO-C101, LY3410738, Binimetinib, DEBIO 1124, CDK-002, ONC201, GI 6207, APS03118, exoASO STAT6, and others

 

Dive deep into rich insights into new Thyroid Cancer Emerging Therapies, visit @ Thyroid Cancer Drugs

 

Table of content

  1. Introduction
  2. Executive Summary
  3. Thyroid Cancer: Overview
  4. Pipeline Therapeutics
  5. Therapeutic Assessment
  6. Thyroid Cancer– DelveInsight’s Analytical Perspective
  7. Late Stage Products (Phase III)
  8. Donafenib: Suzhou Zelgen Biopharmaceuticals
  9. Drug profiles in the detailed report…..
  10. Mid Stage Products (Phase II)
  11. Nivolumab: Bristol-Myers Squibb
  12. Drug profiles in the detailed report…..
  13. Early Stage Products (Phase I) 
  14. AIC100: Affyimmune Therapeutics
  15. Drug profiles in the detailed report…..
  16. Preclinical and Discovery Stage Products 
  17. Drug name: Company name
  18. Drug profiles in the detailed report…..
  19. Inactive Products
  20. Thyroid Cancer Key Companies
  21. Thyroid Cancer Key Products
  22. Thyroid Cancer- Unmet Needs
  23. Thyroid Cancer- Market Drivers and Barriers
  24. Thyroid Cancer- Future Perspectives and Conclusion
  25. Thyroid Cancer Analyst Views
  26. Thyroid Cancer Key Companies
  27. Appendix

 

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Thyroid Cancer drugs?
  • How many Thyroid Cancer drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Thyroid Cancer?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Thyroid Cancer therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Thyroid Cancer and their status?
  • What are the key designations that have been granted to the emerging drugs?

 

For further information on the Thyroid Cancer pipeline therapeutics, reach out Thyroid Cancer Pipeline Outlook Report

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